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Single-base lesions are eliminated by base excision repair (BER), a pathway initiated by DNA glycosylases that recognize and excise damaged bases. Base removal ...
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Oct 8, 2008 · Human alkyladenine DNA glycosylase (AAG) is a 33 kD monomeric protein that initiates repair of a diverse group of alkylated and deaminated ...
Jun 20, 2023 · The human ligase IIIα-XRCC1 protein complex performs DNA Nick repair after transient unwrapping of nucleosomal DNA. J. Biol. Chem. 292, 5227 ...
Jul 5, 2021 · Such a mechanism enables hNEIL1 to process a series of structurally diverse substrates while minimizes the risk of erroneous cleavage of normal ...
Introduction to the HhH DNA glycosylase superfamily: a versatile platform for DNA repair. Base Excision Repair (BER)is a highly conserved DNA repair pathway ...
DNA N-glycosylases are base excision-repair proteins that locate and cleave damaged bases from DNA as the first step in restoring the genetic blueprint.
Search for DNA damage by human alkyladenine DNA glycosylase ...
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In human alkyladenine DNA glycosylase (AAG), the enzyme that initiates base excision repair of alkylated bases, the flipped-out nucleotide is stabilized by ...
Mar 4, 2010 · Our results indicate that AAG uses hopping to effectively search both strands of a DNA duplex in a single binding encounter. This raised the ...
Dec 11, 2000 · The human 3-methyladenine DNA glycosylase [alkyladenine DNA glycosylase (AAG)] catalyzes the first step of base excision repair by cleaving ...
Damage recognition and excision by these and other glycosylases rely on a base‐flipping mechanism, whereby the damaged nucleotide is rotated ~180° around the ...